Yes I definitely believe the. 357 Sig would make a nastier wound than the 45. because 125 grain Sig round is the equivalent of a .357 Magnum. I also think that some 9mm would depending on load because the 45 depends more on frontal diameter and bullet weight and it's hard to get reliable expansion from the 45 unless you go all the way down to say 185 grain +p loads. Everything I have ever seen read and heard seems to verify that it takes 1000 fps for reliable expansion and none of the 230 grain loads can produce that. I think the. 357 Sig is better than the 45 or. 357 Magnum either and I have all three. The Sig is a pleasure to shoot with hardly any more recoil than a hot 9mm and in some cases over double the capacity of either the 45 or. 357 Magnum.